LSH mediates gene repression through macroH2A deposition

The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.

Bibliographic Details
Main Authors: Kai Ni, Jianke Ren, Xiaoping Xu, Yafeng He, Richard Finney, Simon M. G. Braun, Nathaniel A. Hathaway, Gerald R. Crabtree, Kathrin Muegge
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19159-0