LSH mediates gene repression through macroH2A deposition
The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19159-0 |
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doaj-6643f55537234e79b58f4c93aa3e4891 |
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Article |
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doaj-6643f55537234e79b58f4c93aa3e48912021-05-11T08:51:15ZengNature Publishing GroupNature Communications2041-17232020-11-0111111410.1038/s41467-020-19159-0LSH mediates gene repression through macroH2A depositionKai Ni0Jianke Ren1Xiaoping Xu2Yafeng He3Richard Finney4Simon M. G. Braun5Nathaniel A. Hathaway6Gerald R. Crabtree7Kathrin Muegge8Mouse Cancer Genetics Program, National Cancer InstituteMouse Cancer Genetics Program, National Cancer InstituteMouse Cancer Genetics Program, National Cancer InstituteMouse Cancer Genetics Program, National Cancer InstituteCCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer InstituteDepartments of Pathology and Developmental Biology, Stanford University School of MedicineDivision of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of PharmacyDepartments of Pathology and Developmental Biology, Stanford University School of MedicineMouse Cancer Genetics Program, National Cancer InstituteThe human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.https://doi.org/10.1038/s41467-020-19159-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kai Ni Jianke Ren Xiaoping Xu Yafeng He Richard Finney Simon M. G. Braun Nathaniel A. Hathaway Gerald R. Crabtree Kathrin Muegge |
| spellingShingle |
Kai Ni Jianke Ren Xiaoping Xu Yafeng He Richard Finney Simon M. G. Braun Nathaniel A. Hathaway Gerald R. Crabtree Kathrin Muegge LSH mediates gene repression through macroH2A deposition Nature Communications |
| author_facet |
Kai Ni Jianke Ren Xiaoping Xu Yafeng He Richard Finney Simon M. G. Braun Nathaniel A. Hathaway Gerald R. Crabtree Kathrin Muegge |
| author_sort |
Kai Ni |
| title |
LSH mediates gene repression through macroH2A deposition |
| title_short |
LSH mediates gene repression through macroH2A deposition |
| title_full |
LSH mediates gene repression through macroH2A deposition |
| title_fullStr |
LSH mediates gene repression through macroH2A deposition |
| title_full_unstemmed |
LSH mediates gene repression through macroH2A deposition |
| title_sort |
lsh mediates gene repression through macroh2a deposition |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription. |
| url |
https://doi.org/10.1038/s41467-020-19159-0 |
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