Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
Alpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the synucleinopathies present as Lewy bodies in Parkinson’s disease, dementia with Lewy bodies, or glial cytoplasmic inclusions in multiple system atrophy. These neurodegenerative diseases also exhibit cell...
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doaj-66466c9a0216457193df92d71a853b162020-11-25T00:31:13ZengMDPI AGCells2073-44092019-06-018656510.3390/cells8060565cells8060565Autophagy in Synucleinopathy: The Overwhelmed and Defective MachineryMarie-Laure Arotcarena0Margaux Teil1Benjamin Dehay2Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, FranceUniv. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, FranceUniv. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, FranceAlpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the synucleinopathies present as Lewy bodies in Parkinson’s disease, dementia with Lewy bodies, or glial cytoplasmic inclusions in multiple system atrophy. These neurodegenerative diseases also exhibit cellular dyshomeostasis, such as autophagy impairment. Several decades of research have questioned the potential link between the autophagy machinery and alpha-synuclein protein toxicity in synucleinopathy and neurodegenerative processes. Here, we aimed to discuss the active participation of autophagy impairment in alpha-synuclein accumulation and propagation, as well as alpha-synuclein-independent neurodegenerative processes in the field of synucleinopathy. Therapeutic approaches targeting the restoration of autophagy have started to emerge as relevant strategies to reverse pathological features in synucleinopathies.https://www.mdpi.com/2073-4409/8/6/565Parkinson’s diseasemultiple system atrophysynucleinopathyα-synucleinmacroautophagychaperone-mediated autophagymitophagyneurodegeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marie-Laure Arotcarena Margaux Teil Benjamin Dehay |
spellingShingle |
Marie-Laure Arotcarena Margaux Teil Benjamin Dehay Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery Cells Parkinson’s disease multiple system atrophy synucleinopathy α-synuclein macroautophagy chaperone-mediated autophagy mitophagy neurodegeneration |
author_facet |
Marie-Laure Arotcarena Margaux Teil Benjamin Dehay |
author_sort |
Marie-Laure Arotcarena |
title |
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery |
title_short |
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery |
title_full |
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery |
title_fullStr |
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery |
title_full_unstemmed |
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery |
title_sort |
autophagy in synucleinopathy: the overwhelmed and defective machinery |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2019-06-01 |
description |
Alpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the synucleinopathies present as Lewy bodies in Parkinson’s disease, dementia with Lewy bodies, or glial cytoplasmic inclusions in multiple system atrophy. These neurodegenerative diseases also exhibit cellular dyshomeostasis, such as autophagy impairment. Several decades of research have questioned the potential link between the autophagy machinery and alpha-synuclein protein toxicity in synucleinopathy and neurodegenerative processes. Here, we aimed to discuss the active participation of autophagy impairment in alpha-synuclein accumulation and propagation, as well as alpha-synuclein-independent neurodegenerative processes in the field of synucleinopathy. Therapeutic approaches targeting the restoration of autophagy have started to emerge as relevant strategies to reverse pathological features in synucleinopathies. |
topic |
Parkinson’s disease multiple system atrophy synucleinopathy α-synuclein macroautophagy chaperone-mediated autophagy mitophagy neurodegeneration |
url |
https://www.mdpi.com/2073-4409/8/6/565 |
work_keys_str_mv |
AT marielaurearotcarena autophagyinsynucleinopathytheoverwhelmedanddefectivemachinery AT margauxteil autophagyinsynucleinopathytheoverwhelmedanddefectivemachinery AT benjamindehay autophagyinsynucleinopathytheoverwhelmedanddefectivemachinery |
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1725323091669680128 |