CD8+ T cells as immune regulators of multiple sclerosis

CD8+ T cells as immune regulators of multiple sclerosis

The vast majority of studies regarding the immune basis of MS (and its animal model, EAE) has largely focused on CD4+ T-cells as mediators and regulators of disease. Interestingly, CD8+ T-cells represent the predominant T-cell population in human MS lesions and are oligoclonally expanded at the site...

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Bibliographic Details
Main Authors: Sushmita eSinha, Alexander eBoyden, Farah eItani, Michael eCrawford, Nitin eKarandikar
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Immunology
Subjects:
Multiple Sclerosis
EAE
Immune Regulation
T-cells
CD8
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00619/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00619/full

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