NIH3T3 Directs Memory-Fated CTL Programming and Represses High Expression of PD-1 on Antitumor CTLs

NIH3T3 Directs Memory-Fated CTL Programming and Represses High Expression of PD-1 on Antitumor CTLs

Memory CD8+ T cells have long been considered a promising population for adoptive cell therapy (ACT) due to their long-term persistence and robust re-stimulatory response. NIH3T3 is an immortalized mouse embryonic fibroblast cell line. We report that NIH3T3-conditioned medium (CM) can augment effect...

Full description

Bibliographic Details
Main Authors: Yingyu Qin, Yuna Lee, Jaeho Seo, Taehyun Kim, Jung Hoon Shin, Se-Ho Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
NIH3T3-CM
cytotoxic T lymphocytes
memory precursor
memory CD8+ T cells
adoptive cell therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00761/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00761/full

Similar Items