Myosin Assembly, Maintenance and Degradation in Muscle: Role of the Chaperone UNC-45 in Myosin Thick Filament Dynamics

Myosin Assembly, Maintenance and Degradation in Muscle: Role of the Chaperone UNC-45 in Myosin Thick Filament Dynamics

Myofibrillogenesis in striated muscle cells requires a precise ordered pathway to assemble different proteins into a linear array of sarcomeres. The sarcomere relies on interdigitated thick and thin filaments to ensure muscle contraction, as well as properly folded and catalytically active myosin he...

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Bibliographic Details
Main Authors: David B. Pilgrim, Torah M. Kachur
Format: Article
Language:English
Published: MDPI AG 2008-09-01
Series:International Journal of Molecular Sciences
Subjects:
Myosin
chaperone
protein folding
UNC-45
motor domain
heat shock protein
Online Access:http://www.mdpi.com/1422-0067/9/9/1863/

Internet

http://www.mdpi.com/1422-0067/9/9/1863/

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