Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation

Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation

DNA (cytosine-5)-methyltransferase 3A (DNMT3A)-mutated acute myeloid leukemia (AML) has a poor prognosis, but the exact mechanism is still unclear. Here, we aimed to explore the mechanism of immune escape in AML with DNMT3A mutation. We constructed a DNMT3A knockout clone and DNMT3A-R882H-mutated cl...

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Bibliographic Details
Main Authors: Yimei Que, Huimin Li, Liman Lin, Xiaojian Zhu, Min Xiao, Ying Wang, Li Zhu, Dengju Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
AML
DNMT3A
macrophage polarization
immune escape
immune microenvironment
epigenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.653030/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.653030/full

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