CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis

ß2 integrin receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit, and are differentially expressed by leukocytes. ß2 integrins are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Functiona...

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Bibliographic Details
Main Authors: Daniel Teschner, Anna Cholaszczyńska, Frederic Ries, Hendrik Beckert, Matthias Theobald, Stephan Grabbe, Markus Radsak, Matthias Bros
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
Aspergillus fumigatus
pneumonia
β2 integrins
CD11b
complement receptor 3
polymorphonuclear neutrophils
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00123/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00123/full

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