TrkB overexpression in mice buffers against memory deficits and depression-like behavior but not all anxiety- and stress-related symptoms induced by developmental exposure to methylmercury

TrkB overexpression in mice buffers against memory deficits and depression-like behavior but not all anxiety- and stress-related symptoms induced by developmental exposure to methylmercury

Developmental exposure to low dose of methylmercury (MeHg) has a long-lasting effect on memory and attention deficits in humans, as well as cognitive performance, depression-like behavior and the hippocampal levels of the brain-derived neurotrophic factor (Bdnf)in mice. The Bdnf receptor TrkB is a k...

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Bibliographic Details
Main Authors: Nina N Karpova, Jesse Saku Olavi Lindholm, Natalia eKulesskaya, Natalia eOnishchenko, Marie eVahter, Dina ePopova, Sandra eCeccatelli, Eero eCastren
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anxiety
Brain-Derived Neurotrophic Factor
Glutathione Reductase
Hippocampus
Glyoxalase
perinatal methylmercury
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00315/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00315/full

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