Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation

Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation

Background: Mitochondrial succinate accumulation has been suggested as key event for ischemia reperfusion injury in mice. No specific data are however available on behavior of liver mitochondria during ex situ machine perfusion in clinical transplant models. Methods: We investigated mitochondrial me...

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Bibliographic Details
Main Authors: Andrea Schlegel, Xavier Muller, Matteo Mueller, Anna Stepanova, Philipp Kron, Olivier de Rougemont, Paolo Muiesan, Pierre-Alain Clavien, Alexander Galkin, David Meierhofer, Philipp Dutkowski
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
FMN
Complex I
Hypothermic oxygenated perfusion
Normothermic oxygenated perfusion
Liver transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642030390X

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http://www.sciencedirect.com/science/article/pii/S235239642030390X

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