Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1

Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1

ABSTRACT: Background: Structure–activity relationship studies improve the pharmacological and pharmacokinetic properties of a lead compound such as PSNCBAM-1, an allosteric modulator of the cannabinoid receptor 1. Objectives: Here, several derivatives of PSNCBAM-1 were synthesized with the aim of r...

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Bibliographic Details
Main Authors: Rachel Dopart, Sri Sujana Immadi, Dai Lu, Debra A. Kendall
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Current Therapeutic Research
Subjects:
allosteric modulator
cannabinoid
CB1 receptor
diarylurea
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X19300232

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http://www.sciencedirect.com/science/article/pii/S0011393X19300232

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