Circulating Metabolomic Signature in Generalized Pustular Psoriasis Blunts Monocyte Hyperinflammation by Triggering Amino Acid Response

Circulating Metabolomic Signature in Generalized Pustular Psoriasis Blunts Monocyte Hyperinflammation by Triggering Amino Acid Response

Generalized pustular psoriasis (GPP), the most grievous variant of psoriasis, is featured by dysregulated systemic inflammatory response. The cellular and molecular basis of GPP is poorly understood. Blood monocytes are key players of host defense and producers of inflammatory cytokines including IL...

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Bibliographic Details
Main Authors: Ning Yu, Chen Peng, Wenjuan Chen, Ziwen Sun, Jianfeng Zheng, Shujie Zhang, Yangfeng Ding, Yuling Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
generalized pustular psoriasis
metabolomics
amino acid
monocyte
GCN2 2
IL-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.739514/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.739514/full

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