Identification of human TERT elements necessary for telomerase recruitment to telomeres

Identification of human TERT elements necessary for telomerase recruitment to telomeres

Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch, on the OB-fold domain of the shelterin compo...

Full description

Bibliographic Details
Main Authors: Jens C Schmidt, Andrew B Dalby, Thomas R Cech
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
telomerase
telomere
recruitment
TEN-domain
cancer
Online Access:https://elifesciences.org/articles/03563

Internet

https://elifesciences.org/articles/03563

Similar Items