High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis

High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis

Purpose: Our previous study indicated that mitochondrial DNA (mtDNA) damage and mutations are crucial to the progressive loss of retinal ganglion cells (RGCs) in a glaucomatous rat model. In this study, we examined whether high pressure could directly cause mtDNA alterations and whether the latter c...

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Bibliographic Details
Main Authors: Sheng-Hai Zhang, Feng-Juan Gao, Zhong-Mou Sun, Ping Xu, Jun-Yi Chen, Xing-Huai Sun, Ji-Hong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hydrostatic Pressure
Mutation
Retinal Ganglion Cells
Mitochondrial dysfunction
mitochondrial DNA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00254/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00254/full

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