Downregulation of miR-503 in Activated Kidney Fibroblasts Disinhibits KCNN4 in an in Vitro Model of Kidney Fibrosis

Background/Aims: Activated fibroblasts are key controllers of extracellular matrix turnover in kidney fibrosis, the pathophysiological end stage of chronic kidney disease. The proliferation of activated fibroblasts depends on the expression of the calcium-dependent potassium channel KCNN4. Expressio...

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Bibliographic Details
Main Authors: Christoph Mann, Brajesh Pratap Kaistha, Michael Kacik, Thorsten Stiewe, Joachim Hoyer
Format: Article
Language:English
Published: Karger Publishers 2019-02-01
Series:Kidney & Blood Pressure Research
Subjects:
Online Access:https://www.karger.com/Article/FullText/498875