EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer

EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer

Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been detected in neuronal cells. We hypothesized...

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Bibliographic Details
Main Authors: Caroline J. Atkinson, Futoshi Kawamata, Cheng Liu, Sunyoung Ham, Balázs Győrffy, Alan L. Munn, Ming Q. Wei, Andreas Möller, Vicki Whitehall, Adrian P. Wiegmans
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Molecular Oncology
Subjects:
cisplatin
colorectal cancer
FOXO3a
Prion protein
signal transduction
Online Access:https://doi.org/10.1002/1878-0261.12411

Internet

https://doi.org/10.1002/1878-0261.12411

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