Type and Gene Location of <i>KIT</i> Mutations Predict Progression-Free Survival to First-Line Imatinib in Gastrointestinal Stromal Tumors: A Look into the Exon

Type and Gene Location of <i>KIT</i> Mutations Predict Progression-Free Survival to First-Line Imatinib in Gastrointestinal Stromal Tumors: A Look into the Exon

In previous studies on localized GISTs, <i>KIT</i> exon 11 deletions and mutations involving codons 557/558 showed an adverse prognostic influence on recurrence-free survival. In the metastatic setting, there are limited data on how mutation type and codon location might contribute to pr...

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Bibliographic Details
Main Authors: Lorena Incorvaia, Daniele Fanale, Bruno Vincenzi, Ida De Luca, Tommaso Vincenzo Bartolotta, Roberto Cannella, Gianni Pantuso, Daniela Cabibi, Antonio Russo, Viviana Bazan, Giuseppe Badalamenti
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
gastrointestinal stromal tumors
GIST
imatinib
KIT
mutations
predictive biomarkers
Online Access:https://www.mdpi.com/2072-6694/13/5/993

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https://www.mdpi.com/2072-6694/13/5/993

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