Characterization of Tolerance Induction through Prenatal Marrow Transplantation: The Requirement for a Threshold Level of Chimerism to Establish Rather than Maintain Postnatal Skin Tolerance

Characterization of Tolerance Induction through Prenatal Marrow Transplantation: The Requirement for a Threshold Level of Chimerism to Establish Rather than Maintain Postnatal Skin Tolerance

Hematopoietic chimerism resulting from prenatal marrow transplantation does not consistently result in allotolerance for unidentified causes. In a C57BL/6-into-FVB/N murine model, we transplanted T-cell-depleted adult marrow on gestational day 14 to elucidate the immunological significance of chimer...

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Main Authors: Jeng-Chang Chen M.D., Ming-Ling Kuo Ph.D., Liang-Shiou Ou, Pei-Yeh Chang, Marcus O. Muench, Chia-Rui Shen, Hsueh-Ling Chang, Hsiu-Yueh Yu, Ren-Huei Fu
Format: Article
Language:English
Published: SAGE Publishing 2010-12-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368910X516583

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https://doi.org/10.3727/096368910X516583

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