Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites

An optimized, convergent, safe synthesis of piperaquine phosphate (1), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for piperaquine phosphate (1) production were made in the preparation of intermediate 7 by using directly piperazine instead of...

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Bibliographic Details
Main Authors: Nguyen Van Hung, Pham Van Cuong, Doan Thi Mai Huong, Tran Van Hieu, Chau Van Minh
Format: Article
Language:English
Published: SpringerOpen 2011-12-01
Series:Journal of Analytical Science and Technology
Subjects:
Online Access:http://www.jastmag.org/journal/view.php?Type=C&number=82