Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites
An optimized, convergent, safe synthesis of piperaquine phosphate (1), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for piperaquine phosphate (1) production were made in the preparation of intermediate 7 by using directly piperazine instead of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2011-12-01
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| Series: | Journal of Analytical Science and Technology |
| Subjects: | |
| Online Access: | http://www.jastmag.org/journal/view.php?Type=C&number=82 |
| Summary: | An optimized, convergent, safe synthesis of piperaquine phosphate (1), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for piperaquine phosphate (1) production were made in the preparation of intermediate 7 by using directly piperazine instead of N-formyl piperazine. The structures of the synthetic compounds were determined from spectral analysis including MS and 2D NMR. |
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| ISSN: | 2093-3134 2093-3371 |