Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites

An optimized, convergent, safe synthesis of piperaquine phosphate (1), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for piperaquine phosphate (1) production were made in the preparation of intermediate 7 by using directly piperazine instead of...

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Main Authors:	Nguyen Van Hung, Pham Van Cuong, Doan Thi Mai Huong, Tran Van Hieu, Chau Van Minh
Format:	Article
Language:	English
Published:	SpringerOpen 2011-12-01
Series:	Journal of Analytical Science and Technology
Subjects:	piperaquine piperaquine metabolites antimalaria synthesis
Online Access:	http://www.jastmag.org/journal/view.php?Type=C&number=82

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spelling	doaj-668163aa15e241ecb3ab00c868be43eb2020-11-24T22:02:43ZengSpringerOpenJournal of Analytical Science and Technology2093-31342093-33712011-12-012Supplement AA183A188Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolitesNguyen Van HungPham Van CuongDoan Thi Mai HuongTran Van HieuChau Van MinhAn optimized, convergent, safe synthesis of piperaquine phosphate (1), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for piperaquine phosphate (1) production were made in the preparation of intermediate 7 by using directly piperazine instead of N-formyl piperazine. The structures of the synthetic compounds were determined from spectral analysis including MS and 2D NMR.http://www.jastmag.org/journal/view.php?Type=C&number=82piperaquinepiperaquine metabolitesantimalariasynthesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nguyen Van Hung Pham Van Cuong Doan Thi Mai Huong Tran Van Hieu Chau Van Minh
spellingShingle	Nguyen Van Hung Pham Van Cuong Doan Thi Mai Huong Tran Van Hieu Chau Van Minh Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites Journal of Analytical Science and Technology piperaquine piperaquine metabolites antimalaria synthesis
author_facet	Nguyen Van Hung Pham Van Cuong Doan Thi Mai Huong Tran Van Hieu Chau Van Minh
author_sort	Nguyen Van Hung
title	Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites
title_short	Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites
title_full	Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites
title_fullStr	Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites
title_full_unstemmed	Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites
title_sort	pilot plant production of anti-malarial drug piperaquine phosphate and synthesis of its metabolites
publisher	SpringerOpen
series	Journal of Analytical Science and Technology
issn	2093-3134 2093-3371
publishDate	2011-12-01
description	An optimized, convergent, safe synthesis of piperaquine phosphate (1), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for piperaquine phosphate (1) production were made in the preparation of intermediate 7 by using directly piperazine instead of N-formyl piperazine. The structures of the synthetic compounds were determined from spectral analysis including MS and 2D NMR.
topic	piperaquine piperaquine metabolites antimalaria synthesis
url	http://www.jastmag.org/journal/view.php?Type=C&number=82
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Pilot plant production of Anti-malarial Drug piperaquine phosphate and synthesis of its metabolites

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