Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin

Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin

Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to ai...

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Bibliographic Details
Main Authors: Amir Ata Saei, Hjalmar Gullberg, Pierre Sabatier, Christian M. Beusch, Katarina Johansson, Bo Lundgren, Per I. Arvidsson, Elias S.J. Arnér, Roman A. Zubarev
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
Ligand
Mechanism of action
Protein expression
Melting temperature
Target
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720302433

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http://www.sciencedirect.com/science/article/pii/S2213231720302433

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