Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons

<p>Abstract</p> <p>Background</p> <p>Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin. H...

Full description

Bibliographic Details
Main Authors: Ouyang Xiaosen, Liang Qiuli, Schneider Lonnie, Zhang Jianhua
Format: Article
Language:English
Published: BMC 2011-06-01
Series:Molecular Neurodegeneration
Subjects:
Online Access:http://www.molecularneurodegeneration.com/content/6/1/37