Direct generation of neurosphere-like cells from human dermal fibroblasts.

Neural stem cell (NSC) transplantation replaces damaged brain cells and provides disease-modifying effects in many neurological disorders. However, there has been no efficient way to obtain autologous NSCs in patients. Given that ectopic factors can reprogram somatic cells to be pluripotent, we atte...

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Bibliographic Details
Main Authors: Soon-Tae Lee, Kon Chu, Keun-Hwa Jung, Young-Mi Song, Daejong Jeon, Seung U Kim, Manho Kim, Sang Kun Lee, Jae-Kyu Roh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3135606?pdf=render