Pharmaco-fUS: Quantification of pharmacologically-induced dynamic changes in brain perfusion and connectivity by functional ultrasound imaging in awake mice

Pharmaco-fUS: Quantification of pharmacologically-induced dynamic changes in brain perfusion and connectivity by functional ultrasound imaging in awake mice

There is a critical need for reliable quantitative biomarkers to assess functional brain alterations in mouse models of neuropsychiatric diseases, but current imaging methods measuring drug effects through the neurovascular coupling, face issues including poor sensitivity, drug-induced changes in gl...

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Bibliographic Details
Main Authors: Claire Rabut, Jérémy Ferrier, Adrien Bertolo, Bruno Osmanski, Xavier Mousset, Sophie Pezet, Thomas Deffieux, Zsolt Lenkei, Mickaël Tanter
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:NeuroImage
Subjects:
Functional ultrasound imaging
Awake imaging
Functional biomarker
Support Vector Machine classifier
Drug effects monitoring
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920307175

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http://www.sciencedirect.com/science/article/pii/S1053811920307175

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