Mapping Alterations Induced by Long-Term Axenic Cultivation of Leishmania amazonensis Promastigotes With a Multiplatform Metabolomic Fingerprint Approach

Mapping Alterations Induced by Long-Term Axenic Cultivation of Leishmania amazonensis Promastigotes With a Multiplatform Metabolomic Fingerprint Approach

Leishmaniases are widespread neglected diseases with an incidence of 1.6 million new cases and 40 thousand deaths per year. Leishmania parasites may show distinct, species-specific patterns of virulence that lead to different clinical manifestations. It is well known that successive in vitro passage...

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Bibliographic Details
Main Authors: Frederico Crepaldi, Juliano Simões de Toledo, Anderson Oliveira do Carmo, Leopoldo Ferreira Marques Machado, Daniela Diniz Viana de Brito, Angela Vieira Serufo, Ana Paula Martins Almeida, Leandro Gonzaga de Oliveira, Tiago Queiroga Nery Ricotta, Douglas de Souza Moreira, Silvane Maria Fonseca Murta, Ariane Barros Diniz, Gustavo Batista Menezes, Ángeles López-Gonzálvez, Coral Barbas, Ana Paula Fernandes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
L. amazonensis
attenuation
metacyclogenesis
inflammation
multiplatform metabolomic fingerprint
metabolic pathways
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00403/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00403/full

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