Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, conferring neuroprotection. Betulinic acid (BA) is a naturally pentacyclic triterpenoid with considerable anti-inflammatory prop...

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Bibliographic Details
Main Authors: Chuwen Li, Chao Zhang, Hefeng Zhou, Yu Feng, Fan Tang, Maggie P. M. Hoi, Chengwei He, Dan Ma, Chao Zhao, Simon M. Y. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
AMP-activated protein kinase
betulinic acid
calmodulin-dependent protein kinase β
microglia polarization
neuroinflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00098/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00098/full

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