Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung Disease

Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung Disease

Cystic fibrosis (CF), a fatal genetic disorder predominant in the Caucasian population, is caused by mutations in the cystic fibrosis transmembrane conductance regulator (Cftr) gene. The most common mutation is the deletion of phenylalanine from the position-508 (F508del-CFTR), resulting in a misfol...

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Bibliographic Details
Main Authors: Manish Bodas, Neeraj Vij
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
proteostasis
autophagy
cystic fibrosis
CFTR
ROS
protein-misfolding
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00020/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00020/full

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