Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis

Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis

Abstract Background Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient’s quality of life. However, the pathogenetic mechanism of hand osteoarthritis (hand OA) is still elu...

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Bibliographic Details
Main Authors: Jiawen Xu, Yi Zeng, Haibo Si, Yuan Liu, Mingyang Li, Junfeng Zeng, Bin Shen
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Arthritis Research & Therapy
Subjects:
Hand osteoarthritis
Transcriptome-wide association study (TWAS)
mRNA expression profile
Gene ontology (GO)
Pathway enrichment analysis
Online Access:https://doi.org/10.1186/s13075-021-02458-2

Internet

https://doi.org/10.1186/s13075-021-02458-2

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