α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parki...
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Bibliographic Details
Main Authors: |
Marthe H. R. Ludtmann,
Plamena R. Angelova,
Mathew H. Horrocks,
Minee L. Choi,
Margarida Rodrigues,
Artyom Y. Baev,
Alexey V. Berezhnov,
Zhi Yao,
Daniel Little,
Blerida Banushi,
Afnan Saleh Al-Menhali,
Rohan T. Ranasinghe,
Daniel R. Whiten,
Ratsuda Yapom,
Karamjit Singh Dolt,
Michael J. Devine,
Paul Gissen,
Tilo Kunath,
Morana Jaganjac,
Evgeny V. Pavlov,
David Klenerman,
Andrey Y. Abramov,
Sonia Gandhi |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2018-06-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-04422-2
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