Single molecule imaging of protein aggregation in Dementia: Methods, insights and prospects

by John S.H. Danial, David Klenerman
Published 2021-06-01

Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme

by Rachel Cliffe, Jason C. Sang, Franziska Kundel, Daniel Finley, David Klenerman, Yu Ye
Published 2019-02-01

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

by Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Published 2021-05-01

Nanopore extended field-effect transistor for selective single-molecule biosensing

by Ren Ren, Yanjun Zhang, Binoy Paulose Nadappuram, Bernice Akpinar, David Klenerman, Aleksandar P. Ivanov, Joshua B. Edel, Yuri Korchev
Published 2017-09-01

A quantitative comparison of single-dye tracking analysis tools using Monte Carlo simulations.

by Laura Weimann, Kristina A Ganzinger, James McColl, Kate L Irvine, Simon J Davis, Nicholas J Gay, Clare E Bryant, David Klenerman
Published 2013-01-01

Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure

by James H. Felce, Sarah L. Latty, Rachel G. Knox, Susan R. Mattick, Yuan Lui, Steven F. Lee, David Klenerman, Simon J. Davis
Published 2017-09-01

Citrullination of HP1γ chromodomain affects association with chromatin

by Meike Wiese, Andrew J. Bannister, Srinjan Basu, Wayne Boucher, Kai Wohlfahrt, Maria A. Christophorou, Michael L. Nielsen, David Klenerman, Ernest D. Laue, Tony Kouzarides
Published 2019-04-01

Detecting RNA base methylations in single cells by in situ hybridization

by Rohan T. Ranasinghe, Martin R. Challand, Kristina A. Ganzinger, Benjamin W. Lewis, Charlotte Softley, Wolfgang H. Schmied, Mathew H. Horrocks, Nadia Shivji, Jason W. Chin, James Spencer, David Klenerman
Published 2018-02-01

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

by Sarah Louise Latty, Jiro Sakai, Lee Hopkins, Brett Verstak, Teresa Paramo, Nils A Berglund, Eugenia Cammarota, Pietro Cicuta, Nicholas J Gay, Peter J Bond, David Klenerman, Clare E Bryant
Published 2018-01-01

Quantitative single-molecule microscopy reveals that CENP-ACnp1 deposition occurs during G2 in fission yeast

by David Lando, Ulrike Endesfelder, Harald Berger, Lakxmi Subramanian, Paul D. Dunne, James McColl, David Klenerman, Antony M. Carr, Markus Sauer, Robin C. Allshire, Mike Heilemann, Ernest D. Laue
Published 2012-01-01

Virtual-'light-sheet' single-molecule localisation microscopy enables quantitative optical sectioning for super-resolution imaging.

by Matthieu Palayret, Helen Armes, Srinjan Basu, Adam T Watson, Alex Herbert, David Lando, Thomas J Etheridge, Ulrike Endesfelder, Mike Heilemann, Ernest Laue, Antony M Carr, David Klenerman, Steven F Lee
Published 2015-01-01

Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping

by Marie N. Bongiovanni, Julien Godet, Mathew H. Horrocks, Laura Tosatto, Alexander R. Carr, David C. Wirthensohn, Rohan T. Ranasinghe, Ji-Eun Lee, Aleks Ponjavic, Joelle V. Fritz, Christopher M. Dobson, David Klenerman, Steven F. Lee
Published 2016-12-01

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

by Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A. Aprile, Francesco S. Ruggeri, Daniel R. Whiten, Derya Emin, Zengjie Xia, Juan A. Varela, Pietro Sormanni, Franziska Kundel, Tuomas P. J. Knowles, Christopher M. Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman
Published 2019-04-01

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

by Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Published 2019-07-01

Inhibiting the Ca2+ Influx Induced by Human CSF

by Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Published 2017-12-01

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

by Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, Craig D. Hughes, Francesco S. Ruggeri, Tim Guilliams, Alexander K. Buell, Ji-Eun Lee, Sonia Gandhi, Steven F. Lee, Clare E. Bryant, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Erwin De Genst, David Klenerman
Published 2017-07-01

High-resolution label-free 3D mapping of extracellular pH of single living cells

by Yanjun Zhang, Yasufumi Takahashi, Sung Pil Hong, Fengjie Liu, Joanna Bednarska, Philip S. Goff, Pavel Novak, Andrew Shevchuk, Sahana Gopal, Iros Barozzi, Luca Magnani, Hideki Sakai, Yoshimoto Suguru, Takuto Fujii, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Dominik J. Weiss, Christopher Edwards, Aleksandar P. Ivanov, David Klenerman, Elena V. Sviderskaya, Joshua B. Edel, Yuri Korchev
Published 2019-12-01

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

by Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Published 2018-06-01

Impact of S. aureus colonisation in human & mouse populations and relationship to vaccination

by Flaxman, Amy
Published 2017