α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parki...
Main Authors: | Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04422-2 |
Similar Items
-
Proteomic Analysis of Cardiac Adaptation to Exercise by High Resolution Mass Spectrometry
by: Afnan Saleh Al-Menhali, et al.
Published: (2021-09-01) -
Cryopreservation of Human Midbrain Dopaminergic Neural Progenitor Cells Poised for Neuronal Differentiation
by: Nicola J. Drummond, et al.
Published: (2020-11-01) -
Antibody/Ligand-Target Receptor Internalization Assay Protocol Using Fresh Human or Murine Tumor Ex Vivo Samples
by: Shannon R. Joseph, et al.
Published: (2020-09-01) -
The Role of Acrolein and NADPH Oxidase in the Granulocyte-Mediated Growth-Inhibition of Tumor Cells
by: Morana Jaganjac, et al.
Published: (2019-03-01) -
Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron
by: Morana Jaganjac, et al.
Published: (2020-02-01)