CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches

CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches

Abstract Background CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of proinflammatory cytokines, induces T helper cell...

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Bibliographic Details
Main Authors: Maria A. Argiriadi, Lorenzo Benatuil, Ievgeniia Dubrovska, David A. Egan, Lei Gao, Amy Greischar, Jennifer Hardman, John Harlan, Ramesh B. Iyer, Russell A. Judge, Marc Lake, Denise C. Perron, Ramkrishna Sadhukhan, Bernhard Sielaff, Silvino Sousa, Rui Wang, Bradford L. McRae
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Molecular and Cell Biology
Subjects:
CD40
Crystal structure
Agonist
Antagonist
Antibody
Online Access:http://link.springer.com/article/10.1186/s12860-019-0213-4

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http://link.springer.com/article/10.1186/s12860-019-0213-4

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