Whole-Cell Photobleaching Reveals Time-Dependent Compartmentalization of Soluble Proteins by the Axon Initial Segment

Whole-Cell Photobleaching Reveals Time-Dependent Compartmentalization of Soluble Proteins by the Axon Initial Segment

By limiting protein exchange between the soma and the axon, the axon initial segment (AIS) enables the segregation of specific proteins and hence the differentiation of the somatodendritic compartment and the axonal compartment. Electron microscopy and super-resolution fluorescence imaging have prov...

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Bibliographic Details
Main Authors: LaShae Nicholson, Nicolas Gervasi, Thibault Falières, Adrien Leroy, Dorian Miremont, Diana Zala, Cyril Hanus
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuronal polarity
protein compartmentalization
axon initial segment
correlative imaging
super-resolution
fluorescence loss in photobleaching
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00180/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00180/full

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