TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells

TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells

Abstract Background Ten-eleven translocation 1 (TET1) is a dioxygenase that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) to induce DNA demethylation. TET1 has been reported to be absent in cancers, and to influence various oncogenes and anti-oncogenes. However the function of...

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Bibliographic Details
Main Authors: Jian Wu, Hongzhe Li, Minmin Shi, Youwei Zhu, Yang Ma, Yiming Zhong, Cheng Xiong, Hao Chen, Chenghong Peng
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TET1
DNA methylation
Pancreatic tumor
Epithelial-mesenchymal transition
Wnt/β-catenin pathway
Online Access:http://link.springer.com/article/10.1186/s13046-019-1334-5

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http://link.springer.com/article/10.1186/s13046-019-1334-5

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