Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities

Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities

Neurofibromatosis Type 1 (NF1)-related Malignant Peripheral Nerve Sheath Tumors (MPNST) are highly resistant sarcomas that account for significant mortality. The mechanisms of therapy resistance are not well-understood in MPNSTs, particularly with respect to kinase inhibition strategies. In this stu...

Full description

Bibliographic Details
Main Authors: Jamie L. Grit, Matt G. Pridgeon, Curt J. Essenburg, Emily Wolfrum, Zachary B. Madaj, Lisa Turner, Julia Wulfkuhle, Emanuel F. Petricoin, Carrie R. Graveel, Matthew R. Steensma
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Genes
Subjects:
mpnst
nf1
kinase
kinome adaptation
kinome reprogramming
met
mek
doxorubicin
capmatinib
tram
Online Access:https://www.mdpi.com/2073-4425/11/3/331

Internet

https://www.mdpi.com/2073-4425/11/3/331

Similar Items