Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach.

Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Meth). In experiments in rats, SB-334867 (SB), an antagonist of orexin receptors (OX1R), at a dose of 10 mg/kg decreases late temperature responses (t > 60 min) to an intermediate dose of Meth (5 mg/k...

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Bibliographic Details
Main Authors: Abolhassan Behrouzvaziri, Daniel Fu, Patrick Tan, Yeonjoo Yoo, Maria V Zaretskaia, Daniel E Rusyniak, Yaroslav I Molkov, Dmitry V Zaretsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4439171?pdf=render