EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase

EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase

Humans with biallelic inactivating mutations in Epithelial Cell Adhesion Molecule (EpCAM) develop congenital tufting enteropathy (CTE). To gain mechanistic insights regarding EpCAM function in this disorder, we prepared intestinal epithelial cell (IEC) organoids and spheroids. IEC organoids and sphe...

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Bibliographic Details
Main Authors: Takeshi Ouchi, Sohshi Morimura, Lukas E. Dow, Hiroyuki Miyoshi, Mark C. Udey
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
EpCAM
organoid
spheroid
stem cell
ROCK
Online Access:https://www.mdpi.com/2073-4409/10/2/256

Internet

https://www.mdpi.com/2073-4409/10/2/256

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