Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collage...
Main Authors: | , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-02859-z |