Whole-Genome Methylation Analysis of Phenotype Discordant Monozygotic Twins Reveals Novel Epigenetic Perturbation Contributing to the Pathogenesis of Adolescent Idiopathic Scoliosis

Whole-Genome Methylation Analysis of Phenotype Discordant Monozygotic Twins Reveals Novel Epigenetic Perturbation Contributing to the Pathogenesis of Adolescent Idiopathic Scoliosis

Background: Adolescent idiopathic scoliosis (AIS) is a complex disease affecting a large number of teenagers, especially in female. This study reveals novel epigenetic perturbation to the pathogenesis of AIS.Methods: A female monozygotic (MZ) twin pair discordant for AIS were examined for whole-exom...

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Main Authors: Gang Liu, Lianlei Wang, Xinyu Wang, Zihui Yan, Xinzhuang Yang, Mao Lin, Sen Liu, Yuzhi Zuo, Yuchen Niu, Sen Zhao, Yanxue Zhao, Jianguo Zhang, Jianxiong Shen, Yipeng Wang, Guixing Qiu, Zhihong Wu, Nan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
adolescent idiopathic scoliosis (AIS)
monozygotic twins
whole exome sequencing (WES)
DNA methylation
whole genome bisulfite sequencing (WGBS)
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00364/full

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00364/full

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