Cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.

Cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.

Familial hemiplegic migraine type 1 (FHM1) is caused by gain-of-function mutations in CaV2.1 (P/Q-type) Ca2+ channels. Knockin (KI) mice carrying the FHM1 R192Q missense mutation show enhanced cortical excitatory synaptic transmission at pyramidal cell synapses but unaltered cortical inhibitory neur...

Full description

Bibliographic Details
Main Authors: Dania eVecchia, Angelita eTottene, Arn M.J.M. van den Maagdenberg, Daniela ePietrobon
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Synaptic Transmission
Cortex
Migraine
calcium channel
inhibitory
Spreading depression
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00008/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00008/full

Similar Items