Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

Summary: Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated mTOR signaling in mouse microglia leads to phenotypic changes, including an amoeboid-like morphology, increa...

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Bibliographic Details
Main Authors: Xiaofeng Zhao, Yuan Liao, Shannon Morgan, Ramkumar Mathur, Paul Feustel, Joseph Mazurkiewicz, Jiang Qian, Julia Chang, Gary W. Mathern, Matthew A. Adamo, Anthony L. Ritaccio, Michael Gruenthal, Xinjun Zhu, Yunfei Huang
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
epilepsy
epileptogenesis
microglia
seizure
inflammation
astrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301591

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http://www.sciencedirect.com/science/article/pii/S2211124718301591

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