KSAC, a defined Leishmania antigen, plus adjuvant protects against the virulence of L. major transmitted by its natural vector Phlebotomus duboscqi.

KSAC, a defined Leishmania antigen, plus adjuvant protects against the virulence of L. major transmitted by its natural vector Phlebotomus duboscqi.

Recombinant KSAC and L110f are promising Leishmania vaccine candidates. Both antigens formulated in stable emulsions (SE) with the natural TLR4 agonist MPL® and L110f with the synthetic TLR4 agonist GLA in SE protected BALB/c mice against L. major infection following needle challenge. Considering th...

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Bibliographic Details
Main Authors: Regis Gomes, Clarissa Teixeira, Fabiano Oliveira, Phillip G Lawyer, Dia-Eldin Elnaiem, Claudio Meneses, Yasuyuki Goto, Ajay Bhatia, Randall F Howard, Steven G Reed, Jesus G Valenzuela, Shaden Kamhawi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3317914?pdf=render

Internet

http://europepmc.org/articles/PMC3317914?pdf=render

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