Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells

Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells

Abstract Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption of nutrients. The major instigating factor for the immune response in celiac disea...

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Bibliographic Details
Main Authors: Olivier B. Bakker, Aarón D. Ramírez-Sánchez, Zuzanna A. Borek, Niek de Klein, Yang Li, Rutger Modderman, Yvonne Kooy-Winkelaar, Marie K. Johannesen, Filomena Matarese, Joost H. A. Martens, Vinod Kumar, Jeroen van Bergen, Shuo-Wang Qiao, Knut E. A. Lundin, Ludvig M. Sollid, Frits Koning, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86612-5

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https://doi.org/10.1038/s41598-021-86612-5

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