Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

Summary: Brain CD11c+ cells share features with microglia and dendritic cells (DCs). Sterile inflammation increases brain CD11c+ cells, but their phenotype, origin, and functions remain largely unknown. We report that, after cerebral ischemia, microglia attract DCs to the inflamed brain, and astrogl...

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Bibliographic Details
Main Authors: Mattia Gallizioli, Francesc Miró-Mur, Amaia Otxoa-de-Amezaga, Roger Cugota, Angélica Salas-Perdomo, Carles Justicia, Vanessa H. Brait, Francisca Ruiz-Jaén, Maria Arbaizar-Rovirosa, Jordi Pedragosa, Ester Bonfill-Teixidor, Mathias Gelderblom, Tim Magnus, Eva Cano, Carlos del Fresno, David Sancho, Anna M. Planas
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
cerebral ischemia
stroke
antigen- presenting cells
mouse
CCR1
chemokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312808

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http://www.sciencedirect.com/science/article/pii/S2211124720312808

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