CANDLE Syndrome As a Paradigm of Proteasome-Related Autoinflammation

CANDLE Syndrome As a Paradigm of Proteasome-Related Autoinflammation

CANDLE syndrome (Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated temperature) is a rare, genetic autoinflammatory disease due to abnormal functioning of the multicatalytic system proteasome–immunoproteasome. Several recessive mutations in different protein subunits of this s...

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Bibliographic Details
Main Author: Antonio Torrelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
CANDLE
neutrophilic dermatosis
proteasome
immunoproteasome
interferonopathy
autoinflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00927/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00927/full

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