N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides

N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides

Peracetylated N-α-azidoacetylmannosamine (Ac4ManNAz) is metabolized by cells to CMP-azidosialic acid. It has been demonstrated previously that in this way azidosialic acid-containing glycoproteins are formed that can be labeled on the cell surface by a modified Staudinger ligation. Here, we first de...

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Bibliographic Details
Main Authors: Anton P. Bussink, Paul F. van Swieten, Karen Ghauharali, Saskia Scheij, Marco van Eijk, Tom Wennekes, Gijs A. van der Marel, Rolf G. Boot, Johannes M.F.G. Aerts, Herman S. Overkleeft
Format: Article
Language:English
Published: Elsevier 2007-07-01
Series:Journal of Lipid Research
Subjects:
N-acetylmannosamine
iminosugar
azide
Staudinger ligation
sialic acid
chemical ligation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425714

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http://www.sciencedirect.com/science/article/pii/S0022227520425714

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