Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells.

Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells.

To obtain proof of concept for HIV vaccines, we generated recombinant multimeric particles displaying the HIV-1 Envelope (Env) third hypervariable region (V3) as an N-terminal fusion protein on the E2 subunit of the pyruvate dehydrogenase complex of Geobacillus stearothermophilus. The E2 scaffold se...

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Bibliographic Details
Main Authors: Juan Pablo Jaworski, Shelly J Krebs, Maria Trovato, Dina N Kovarik, Zachary Brower, William F Sutton, Garrett Waagmeester, Rossella Sartorius, Luciana D'Apice, Antonella Caivano, Nicole A Doria-Rose, Delphine Malherbe, David C Montefiori, Susan Barnett, Piergiuseppe De Berardinis, Nancy L Haigwood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281069?pdf=render

Internet

http://europepmc.org/articles/PMC3281069?pdf=render

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