Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Comparison of TCA Cycle Intermediates in Human Serum, Plasma, Kasumi-1 Cell and Murine Liver Tissue

Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Comparison of TCA Cycle Intermediates in Human Serum, Plasma, Kasumi-1 Cell and Murine Liver Tissue

The tricarboxylic acid (TCA) cycle is a central part of carbon and energy metabolism, also connecting to glycolysis, amino acid, and lipid metabolism. The quantitation of the TCA cycle intermediate within one method is lucrative due to the interest in central carbon metabolism profiling in cells and...

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Bibliographic Details
Main Authors: Ramji Rathod, Bharat Gajera, Kenneth Nazir, Janne Wallenius, Vidya Velagapudi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Metabolites
Subjects:
tricarboxylic acid (tca) cycle
mass spectrometry
chromatography
metabolites
bioanalytical method validation
Online Access:https://www.mdpi.com/2218-1989/10/3/103

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https://www.mdpi.com/2218-1989/10/3/103

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