Structure and compositional analysis of aluminum oxyhydroxide adsorbed pertussis vaccine

Structure and compositional analysis of aluminum oxyhydroxide adsorbed pertussis vaccine

Purpose: The goal of this study was to characterize an acellular pertussis vaccine (Tdap) containing genetically modified pertussis toxin (gdPT) and TLR agonist adsorbed to AlOOH adjuvant. Methods: Several analytical tools including nanoDSF, FTIR, and LD were used to examine the conformation of nove...

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Bibliographic Details
Main Authors: Jessica Duprez, Kristen Kalbfleisch, Sasmit Deshmukh, Jessie Payne, Manjit Haer, Wayne Williams, Ibrahim Durowoju, Marina Kirkitadze
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Pertussis
Tdap vaccines
TLR agonist
Particle sizing
FTIR
PAT
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020305481

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http://www.sciencedirect.com/science/article/pii/S2001037020305481

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